Your body naturally produces glucosamine, which is key to making cartilage -- flexible tissue in various areas of the body, including the joints. Because of this role, glucosamine supplements are a treatment for osteoarthritis, although not all research supports this use, according to the Beth Israel Deaconess Medical Center in Boston. Other uses include treating tendinitis, sprains and strains and rheumatoid arthritis, but there is not strong scientific backing for these uses.
Dosage Guidelines
To treat osteoarthritis, the suggested dosage for glucosamimine is 1,500 mg daily, taken either in one dose or in three doses of 500 mg each. According to the website Drugs.com, some studies have used up to 3,200 mg, but this higher dose does not seem to afford additional benefit. The University of Maryland Medical Center notes glucosamine is typically used for 30 to 90 days; talk to your doctor about using it longer than this.
Side Effects
At the suggested dosages, glucosamine appears generally safe. Reported side effects are minor and include stomach upset, heartburn, gas and diarrhea. Taking the supplements with food might reduce some of these adverse reactions. If you have an allergy to shellfish, glucosamine supplements might trigger an allergic reaction.
Considerations for Diabetics
Some animal studies and case reports suggest glucosamine might interfere with the hormone insulin's ability to regulate blood sugar, but the Beth Israel Deaconess Medical Center reports more in-depth research into this link suggests it will not cause a problem. If you have diabetes and want to take glucosamine, talk to your doctor, and carefully monitor your blood sugar. You might require an increase in your medications used to control glucose levels.
Other Considerations for Use
Glucosamine might interact with blood-thinning medications. Safety in breastfeeding and pregnant women has not been established. Glucosamine sulfate might have high levels of sodium and potassium, which could prove problematic if you have any condition where you need to watch your intake of these nutrients. In this case, you might want to choose one of the other available forms of glucosamine.
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