Is DHEA Safe?

Is DHEA Safe?
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DHEA, or dehydroepiandrosterone, is naturally produced in the body and converted into the hormones estrogen and androgen, which affect sexual development and function. DHEA has a broad range of uses and has been tested for various conditions including AIDS, Alzheimer's disease and depression. However, its long-term benefits and risks have not been researched as of 2011 and there are some concerns about its safety. Consult with your doctor before using DHEA supplements.

Preparations and Dosage

DHEA supplements are available in tablet, capsule, liquid and sublingual form. Some DHEA is made in the laboratory from substances found in wild yam and soy, but your body cannot make DHEA from these substances. Also be cautious of wild yam and soy products labeled as natural DHEA. The Palo Alto Medical Foundation suggests DHEA doses of 5 to 15mg daily for women and 10 to 30mg daily for men to treat DHEA deficiency.

Less Severe Effects

According to MedlinePlus, DHEA is considered generally safe for most people when used short-term for just a few months. However, it can cause some side effects, such as stomach upset, insomnia, acne and hair loss. DHEA is considered possibly unsafe when taken for a long time in daily doses above 50 to 100mg, because this can increase the risk of side effects, warns MedlinePlus.

Potentially Severe Effects

Potentially severe side effects from DHEA use include problems with liver function, decreased HDL or good cholesterol, high blood pressure and changes in insulin resistance such that insulin becomes less effective at lowering your blood sugar levels. Women may develop a deepened voice, increased facial and body hair growth and menstrual problems. DHEA can cause mania, excitability, irritability and inappropriate sexual behavior in people with mood disorders.

Considerations

If you have diabetes, check your blood sugar levels closely because DHEA can affect how insulin works in your body. Also, insulin for your diabetes can lower DHEA levels in your body and decrease the effectiveness of DHEA supplements. Avoid DHEA if you have a hormone-sensitive condition such as uterine fibroids or breast, uterine or ovarian cancer because DHEA may worsen these conditions. You should not use DHEA if you are pregnant or breastfeeding.

References

Article reviewed by Lisa Michael Last updated on: Jun 15, 2011

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