DHEA, which stands for dehydroepiandrosterone, is a steroid hormone that your body normally makes and converts into the sex hormones estrogen and testosterone among other things. Some people take DHEA supplements to combat aging, improve athletic performance or treat disease. But the effectiveness of DHEA is unproven. Because it is a hormone, DHEA does pose dangers to people with hormone-sensitive conditions and other health issues. Do not take DHEA supplements without talking to your doctor first.
Hormonal Dangers
DHEA can affect sex hormones, causing side effects. In women, this may cause the growth of facial hair, acne, hair loss, sweating, thickening of the waist or a deeper voice. In men, this may cause the testicles to shrink or the breasts to enlarge, increased blood pressure, or aggressiveness. Other hormonal effects include increased blood sugar, insulin resistance and changes in thyroid and adrenal gland function. If you have diabetes or low blood sugar, or any disease of the thyroid or adrenal gland, talk to your doctor before taking DHEA. It may also pose risks for those with hormone-sensitive conditions like cancers of the breast, prostate or ovaries; enlarged prostate; polycystic ovary syndrome; endometriosis; or fibroids. If you are pregnant or breast-feeding, do not take DHEA, as its hormonal effects may endanger the baby. If you are taking the breast cancer drug tamoxifen or hormone replacement therapy, DHEA may interfere with your medication.
Cardiovascular Risks
DHEA may increase the risk of heart disease or stroke, according to the American Cancer Society. If you have a history of abnormal heart rhythms, high cholesterol, high blood pressure or blood clots, DHEA may worsen your condition. Talk to your doctor before taking DHEA supplements.
Mood & Nervous System Effects
DHEA can affect your mood and your nervous system, causing insomnia, delusions, mania, nervousness, irritability or even psychosis. If you have depression or bipolar disorder, DHEA may aggravate your condition. Do not take DHEA without talking to your doctor first.
Precautions
If you have liver disease or Cushing's syndrome, DHEA may aggravate your condition. Do not take DHEA supplements without first consulting your doctor.
Side Effects
DHEA causes few side effects when taken at recommended doses, according to MayoClinic.com. But it can cause tiredness, nasal congestion, hair loss, stomach upset, high blood pressure, headache, acne or rapid or irregular heartbeats. Do not take more than 50 to 100 mg of DHEA per day, as that may increase the risk of side effects, according to MedlinePlus.
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