Ephedrine is a stimulant used in the treatment of asthma and other breathing problems. Guarana -- a caffeine-containing plant -- is sometimes combined with ephedrine for enhanced stimulant effects. Both substances can cause side effects individually and may be dangerous when combined. Understanding the effects of ephedrine and guarana allows you to use both substances more safely. Before using ephedrine, consult a physician to prevent serious adverse effects.
Pharmacology
Guarana is an herbal supplement containing large amounts of caffeine. Like coffee and tea, guarana is used for its mild stimulant effects, which include increased energy, alertness and focus. Ephedrine, a more potent stimulant, occurs naturally in the Ephedra genus of plants. While ephedra supplements have been banned in the U.S., ephedrine can still be found in some asthma and breathing medications. Both guarana and ephedrine produce typical stimulant effects, such as increased heart rate and blood pressure.
Side Effects
Ephedrine is tightly regulated in the U.S. due to its risk for adverse health effects. According to Drug Information Online, common side effects include anxiety, tremors, confusion, difficulty sleeping and nausea. Because it raises heart rate and blood pressure, ephedrine can be dangerous for people with underlying heart conditions. Guarana may cause many of the same side effects as ephedrine. The website eMedTV lists seizures, irregular heartbeat, tachycardia and anxiety as potentially serious side effects of guarana.
Interactions
Ephedrine and guarana have a synergistic effect, with one substance enhancing the effects of the other. The University of Maryland Medical Center states that ephedrine and guarana can cause serious health problems when combined. High blood pressure, heart attack, stroke and other cardiovascular complications are more likely to occur when taking the substances together. Cocaine, amphetamines and other stimulants may also cause dangerous interactions with guarana or ephedrine.
Prevention/Solution
Avoid using ephedrine without a doctor's supervision, especially if you have a chronic health condition such as heart disease. If you're sensitive to caffeine, use caution when taking guarana, as it may cause negative side effects such as jitteriness or insomnia. Follow dosing instructions closely and avoid driving until you know how ephedrine effects you. If you experience severe mood changes, chest pain or other troubling symptoms after taking ephedrine or guarana, seek immediate medical help.
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