Natalizumab is a medication used to manage multiple sclerosis (an autoimmune disease affecting your spinal cord and brain) and Crohn's disease (inflammatory bowel disease). Natalizumab is given intravenously (through your vein) every four weeks at a hospital or clinic.
Progressive Multifocal Encephalopathy
Natalizumab can lead to progressive multifocal encephalopathy (PML), according to RxList.com. The JC virus causes PML. ("JC" refers to the initials of a patient who suffered from PML.) This virus invades your brain and causes such symptoms as clumsiness of your arms or legs, weakness on one side of your body, memory problems, confusion, problems seeing and personality changes. Tell your doctor if you have these overwhelming symptoms.
Effects on Your Digestive Tract
Natalizumab can bring about nausea, stomach pain, indigestion, constipation and flatulence. You may also develop gallstones or a stomach infection called gastroenteritis, according to Drugs.com.
Liver Damage
Natalizumab can cause liver damage. This is known as hepatotoxicity. Your doctor can check your liver enzymes (natural chemicals) to see if they are elevated. When they are elevated, liver injury is likely. According to RxList.com, natalizumab can cause liver damage within six days after its initial use. See your doctor regularly as she can check your liver enzymes while you are on natalizumab.
Effects on Your Kidneys and Lungs
Natalizumab can harm your kidneys and lungs, according to Drugs.com. For example, it may cause urinary incontinence or a urinary tract infection. Natalizumab can make you susceptible to opportunistic respiratory infections, such as pneumocystis carinii pneumonia, bronchopulmonary aspergillosis and pulmonary mycobacterium avium intracellulare. Sinus infections, flu-like symptoms and sore throat are other side effects of natalizumab.
Allergic Reaction
Sometimes, you may be unaware that you are allergic to natalizumab's ingredients. Signs of an allergic reaction include itching, hives, wheezing, trouble breathing and flushing of your skin, says RxList.com. Dizziness, nausea, a rash, hypotension (low blood pressure) and chest pain are additional side effects of natalizumab. Get medical aid to prevent damaging consequences.
Other Side Effects
Natalizumab can affect your mind and lead to depression or suicidal thoughts. According to Drugs.com, you may also develop vaginal infections, irregular menstrual cycles, headaches, dizziness and fainting spells. Muscle pain, joint swelling, fatigue and nausea are other side effects.
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