The substance lecithin is used both medicinally and in the manufacturing process as an emulsifier. Its primary component phosphatidylcholine might offer a number of therapeutic effects. Research suggests lecithin supplementation might help treat the inflammatory bowel disorder ulcerative colitis. Not enough studies have been conducted, however, to make any firm conclusions regarding lecithin's therapeutic effects for this condition.
Connection Between Phosphatidylcholine and Ulcerative Colitis
The colon has a layer of mucus that helps protect it from bacteria and other harmful agents. Phosphatidylcholine comprises a major component of this mucus, and a deficiency contributes to inflammation. Individuals with ulcerative colitis appear to have less phosphatidylcholine in their intestinal mucus, which suggests low levels of this substance might comprise a key factor in the development of this disease.
Research
The results of two German studies published in a 2010 issue of "Digestive Diseases" found supplementation with phosphatidylcholine worked better than placebo in reducing symptoms of ulcerative colitis. In the first study, which involved patients with a poor response to corticosteroids, 50 percent of subjects using the supplement experienced "significant improvement" compared to 10 percent taking a placebo; 80 percent of subjects using the supplement were able to completely stop taking corticosteroids. The second study found phosphytidycholine supplementation resulted in complete remission and cessation of steroid use in 50 percent of the patients being treated, with others being able to reduce their dosage.
Dosage Guidelines
The dosages used in the study range from 2 to 4 g. The Beth Israel Deaconess Medical Center notes that studies like those mentioned above tend to use a form of lecithin that contains 90 percent phosphatidylcholine. Most brands on the market contain about 10 to 20 percent, which suggests these dosages might prove insufficient if using these products. You might require higher doses to compensate for the reduced phosphatidylcholine content; talk to your doctor about an appropriate dose.
Other Considerations for Use
While lecithin supplementation appears generally safe, it is prudent to check with your doctor before taking any type of supplement in certain instances, which include being pregnant or breastfeeding, taking prescription drugs and having a medical condition, particularly liver or kidney disease as these organs are particularly sensitive to what you put in your body.
