S-adenosyl-L-methionine, or SAM-e, is a naturally occurring organic compound that is found throughout nearly every cell and tissue type in your body. SAM-e is responsible for a number for cellular biological functions including immune system support and removal of harmful toxins. SAM-e is also available as a dietary supplement and should be completely avoided if you are pregnant or breastfeeding.
Function of S-Adenosyl-L-Methionine
According to the University of Maryland Medical Center, SAM-e impacts several important biological processes including maintenance of cell membrane potential, immune system function, and the metabolic break down of neurotransmitters such as serotonin and dopamine. Biochemically, SAM-e is an important molecule because it acts as a methyl group donor in a variety of essential chemical reactions. According to MetaCyc.org, SAM-e is produced and maintained by a biochemical cycle known as the SAM-e cycle.
Alternative Benefits of S-Adenosyl-L-Methionine
SAM-e supplementation has been purported to be beneficial in the treatment of certain medical conditions such as alcoholic liver disease and depression. According to MayoClinic.com, SAM-e medication has been clinically studied and deemed potentially beneficial for its effectiveness at treating osteoarthritis. Other conditions that may benefit from SAM-e supplementation include non-pregnant cholestasis and fibromyalgia.
Side Effects of S-Adenosyl-L-Methionine
Relatively few side effects have been reported with the use of SAM-e, which is available as over-the-counter dietary supplements and as prescription intravenous injection. According to Drugs.com, minor side effects of oral SAM-e include mild gastrointestinal discomfort and mild to severe allergic reactions. According to the University of Maryland Medical Center, you should also avoid taking SAM-e with any other medication until consulting with your physician first to avoid any potential side effects.
S-Adenosyl-L-Methionine and Pregnancy
According to MayoClinic.com, you should not consider taking SAM-e if you are an expectant mother or are currently breastfeeding. It has been shown that SAM-e can cross the placental barrier and be delivered through your breast milk; however it is unclear what danger this exposure to SAM-e may pose to your developing child. Until further research has been done, you should avoid SAM-e or get the approval from your health care provider prior to SAM-e supplementation if you are pregnant or breastfeeding.
