Zofran is the trade name for the anti-nausea medication ondansetron. Diabetics can develop nausea due to elevate blood sugar levels or from delayed gastric emptying. Overall, Zofran is a safe medication, but you should only take it under the guidance of a prescribing physician. Zofran does not necessarily cure the cause of the nausea but, rather, treats the symptoms.
Background on Zofran
Zofran works as an anti-emetic by antagonizing serotonin receptors in the brain according to epocrates.com. Zofran is used primarily to prevent vomiting. It is dosed in adults as 4 mg as needed by intravenous, intramuscular or oral preparations. Zofran is also commonly used to prevent nausea related to chemotherapy, radiation and anesthesia.
Zofran Side Effects
Zofran is a relatively safe medication with a limited side effect profile. It is safe in pregnancy and for nausea related to pregnancy. Common side effects of Zofran include headache, constipation, fatigue, diarrhea and itching. If you experience a severe allergic reaction, which can include rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, throat, or tongue, as well as chest or jaw pain, irregular heartbeat or seizures, seek immediate medical assistance.
Diabetic Hyperglycemia
Diabetic hyperglycemia is a condition of high blood sugar levels greater than 200 mg/dL. The common early symptoms include increased urination, increased thirst, vision changes, fatigue and headache. Later symptoms as toxins build up in the body include abdominal pain, nausea, vomiting, coma, dry mouth and confusion. Treatment is aimed at rehydrating patients, controlling blood sugar levels with insulin and managing nausea with anti-emetic medications such as Zofran.
Gastroparesis
Gastroparesis, or delayed gastric emptying, is a side effect of chronic diabetes. Delayed gastric emptying can cause nausea and vomiting. Surgery on the stomach, systemic sclerosis and certain medications can also cause gastroparesis. Erythromycin, metoclopramide and/or serotonin antagonists like Zofran can treat this condition.
