The Signs & Symptoms Of Excess Lysine

Lysine is an essential amino acid, meaning your body cannot produce it on its own and relies on food to obtain adequate amounts. Lysine is important for proper cellular growth, as well as for the production of carnitine, a nutrient that converts fats into energy, which helps lower cholesterol levels. Lysine also helps form collagen, a compound important for bone, tendon, ligament, cartilage and skin health. Despite its benefits, lysine taken in excess can cause side effects. Consult your physician before taking any lysine supplement.

Gallstones

The University of Maryland Medical Center states that excess lysine can cause the formation of gallstones. According to the book, "Essentials of Sports Nutrition and Supplements," lysine increases cholesterol levels, which increases your risk of gallstones. Gallstones are hard, calcified cholesterol deposits found inside your gallbladder that cause pain, fever, jaundice, nausea and vomiting. Gallstones can be a serious condition and may require medication or surgery in extreme cases.

Arginine Deficiency

Lysine competes with another amino acid, arginine, for absorption because of their similar molecular structure. Therefore, excess lysine may cause a deficiency in arginine. According to MayoClinic.com, a deficiency in arginine caused by excess lysine may cause poor wound healing, hair loss, skin rash, constipation and a fatty liver. Take arginine and lysine supplements at separate times to ensure proper absorption of both amino acids.

Cholesterol

One of the benefits of lysine is that it promotes the formation of high-density lipoprotein, or "good," cholesterol. However, too much lysine in your diet may cause your total cholesterol to increase, which may also increase your risk for developing cardiovascular disease. If you already have high total cholesterol, hypertension or atherosclerosis, excessive lysine intake may increase your risk of a heart attack or stroke, according to "Essentials of Sports Nutrition and Supplements."

Gastrointestinal Distress

According to Drugs.com, 1 to 3 g of lysine daily is well-tolerated by most adults and children. However, high amounts of lysine intake may cause gastrointestinal distress, such as diarrhea, nausea and abdominal pain. Lysine supplements are best tolerated when you take them with food, which can increase their absorption and reduce the risk of developing digestive side effects, especially when taken in larger doses.