Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat the inflammation and pain of arthritis, according to Drugs.com. Your doctor may need to adjust your Piroxicam dose if you have a history of such ailments as heart attack, stroke, asthma or kidney or liver disease. Piroxicam is available as a capsule and your doctor may prescribe 20 mg of it daily to relieve your symptoms.
Stroke or Heart Attack
Medline Plus states that if you take Piroxicam for a long period of time, you put yourself at a high risk for developing a heart attack or stroke. Symptoms of a heart attack include sudden chest pain that can radiate to your arm, diaphoresis (sweating) and trouble breathing. Stroke symptoms include slurred speech, numbness or tingling on one side of your body and paralysis of your face or other part of your body. These complications are potentially life-threatening, so get assistance immediately.
Harm to Your Baby
According to Drugs.com, tell your doctor if you are expecting because Piroxicam can potentially harm your baby. Piroxicam also can contaminate your breast milk. Avoid breastfeeding when you take Piroxicam or seek an alternative treatment for your arthritic pain with your doctor's consultation.
Digestive System Side Effects
Piroxicam can cause bleeding, ulcers or perforation of your intestines or stomach, according to Medline Plus. This can occur at any time during treatment. Call your doctor when you experience such symptoms as nausea, vomiting and stomach pain as you may be suffering from these potentially life-threatening conditions.
Major Side Effects
Piroxicam can lead to such major and concerning side effects as rapid weight gain, coughing blood and vomiting material that looks like coffee grounds, states Drugs.com. Infrequent urination, yellow skin or eyes, bruising, muscle weakness, fever, headache, convulsions and blistering of your skin are other major side effects.



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