Neuropathy affects peripheral nerves in the body, particularly those in the hands and feet, and causes pain, tingling, numbness and weakness. In the U.S., diabetes is most often the cause of neuropathy. The makers of Zostrix cream market the product as a way to keep this type of pain at bay.
How Zostrix Works
The active ingredient in Zostrix, capsaicin, comes from the cayenne pepper and can relieve pain when applied topically in a cream. Capsaicin temporarily short-circuits the chemical "substance P," which transfers pain messages to the brain. Once the pain signal is interrupted, the pain is relieved.
Relieving Neuropathy With Zostrix
Zostrix makes two types of the cream. One relieves arthritis pain, while a newer formulation is labeled as "diabetic foot pain relieving cream" and contains .075 percent capsaicin. Users apply a pea-size amount of cream to the affected foot using an applicator pad and rubbing it in until it is absorbed. Zostrix should be used three to four times a day, and the product's manufacturer notes that it may take two to four weeks of continuous use to achieve the best results.
Clinical Studies
A number of studies have found capsaicin to be an effective treatment for diabetic neuropathy. The American Academy of Physical Medicine and Rehabilitation reviewed methods for relieving this type of pain in studies from 1960 through 2008 and found evidence that capsaicin is effective and should be considered for use. A 1991 study in the Archives of Internal Medicine found that 70 percent of patients using capsaicin got pain relief, while only 53 percent applying a placebo found their pain improved.
Warnings
The makers of Zostrix warn that the cream is only to be used externally and that it should not be applied to broken skin. Children under 10 also should not use Zostrix. In addition, if symptoms worsen, if skin blisters while using the product, or if a severe burning sensation or difficulty breathing occur, patients should discontinue use and consult a doctor.
