Before taking any new supplements it is always wise to check whether they are safe and suitable for you. Several supplements are unsuitable for HIV patients. For example, an article published in the February 2006 issue of "AIDS Alert" states that HIV patients taking antiretrovirals should avoid using garlic and St. John's wort supplements, while MedlinePlus notes that HIV patients should avoid fish oil, which may weaken the immune system. Melatonin, however, is not contraindicated for HIV patients in general. Nevertheless, talk to your doctor before using melatonin supplements.
Properties and Therapeutic Indications
Melatonin is secreted by the pineal gland in the brain and maintains the body's circadian rhythm, or "wake-sleep" cycle. University of Maryland Medical Center notes that synthetic melatonin, available in capsules or tablets from pharmacies and health food stores, might also play a role in the treatment of epilepsy, insomnia, jet lag, irritable bowel syndrome and various forms of cancer, including breast cancer and prostate cancer.
Use in HIV Patients
Clinical research findings published in the December 2003 issue of "Infection" identify a link between melatonin levels in the body and HIV progression. Specifically, researchers found that as HIV progresses, melatonin levels are progressively reduced. Research into whether taking a melatonin supplement might be beneficial for HIV patients is lacking. However, an article published in the November 2005 issue of "Immunity and Ageing" states that melatonin may enhance immune function in patients with a compromised immune system.
Administration
University of Maryland Medical Center states that there is no recommended dose for melatonin supplements, because different people will have different responses to its effects. However, it suggests using the lowest amount possible to achieve the desired effect. Your doctor might be able to suggest a suitable dose for whichever condition you are considering using melatonin for.
Safety Considerations
Melatonin supplements might cause side effects including stomach cramps, headache and irritability. Don't take melatonin supplements if you are pregnant or if you are trying to conceive, as it may affect your fertility. It might also make symptoms of depression worse, so consult your doctor before using melatonin supplements if you have depression. It might also interact with other drugs, including some cancer drugs, anticoagulants and blood pressure medicines. Get medical clearance before using melatonin supplements.
References
- "AIDS Alert"; HIV Patients Taking Antiretrovirals Should Avoid Garlic, St. John's Wort. Other Health Products Were Fine; February 2006
- MedlinePlus: Fish Oil; February 2011
- University of Maryland Medical Center: Melatonin; December 2009
- "Infection"; Reduction of Serum Melatonin Levels in HIV-1-Infected Individuals' Parallel Disease Progression: Correlation With Serum Interleukin-12 Levels; G. Nunnari, et al.; December 2003
- "Immunity and Ageing"; Melatonin, Immune Function and Aging; V. Srinivasan, et al.; November 2005
