Your body uses the nutrient carnitine primarily to burn fat for energy and typically can get all it needs from your diet and its own ability to manufacture it. Certain conditions and the use of certain medications can deplete carnitine levels, making supplementation beneficial. It might also have therapeutic applications for various conditions such as those affecting the heart, diabetes and male infertility, though not enough evidence exists to confirm benefits. Some research-based dosage guidelines exist, and it is prudent to stay within these ranges. If you believe taking acetyl-L-carnitine, one of the supplemental forms of carnitine, will address a particular health concern, talk to your doctor about a safe dose and the risks associated with this supplement.
Dosage Guidelines
The University of Pittsburgh Medical Center reports a typical daily dose of acetyl-L-carnitine consists of 500 mg to 3 g daily, depending on the condition being treated. It notes these doses ''appear quite safe''. How much acetyl-L-carnitine constitutes ''too much'' has not been established. Unless your doctor advises you otherwise, however, it is probably not necessary to take more than the doses used in research. Some potentially adverse reactions have been associated with this supplement, and taking large doses is likely to increase the likelihood of those reactions.
Common Side Effects
Many common side effects associated with acetyl-L-carnitine are common in many drugs and supplements, such as nausea, vomiting and upset stomach.
Rare Side Effects
EMed TV reports acetyl-L-carnitine supplements have been associated with other more serious side effects that probably would be more likely if supplement is taken in high doses. They include agitation, depression, confusion, aggressive behavior and manic behavior. The Memorial Sloan Kettering Cancer Center also notes some rare side effects including seizure, hair loss, rash and heartburn. It also notes that high doses might cause body odor.
Other Safety Concerns
Acetyl-L-carnitine might interfere with production of thyroid hormone, which makes use potentially problematic if you suffer from hypothyroidism. The University of Maryland Medical Center advises you to not use this supplement before talking to your doctor, especially if you suffer from peripheral vascular disease, high blood pressure, cirrhosis, diabetes or kidney disease.
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