Chasteberry (sometimes called monk's pepper) is an herb commonly used to treat hormone-related gynecological conditions. Evidence suggests it is most effective in treating breast discomfort and other symptoms associated with pre-menstrual syndrome (PMS). It is not recommended for use in pregnant or breastfeeding women due to lack of scientific evidence regarding its safety and effectiveness. Although the long-term effects of chasteberry use have not been studied, there are some short-term risks of side effects associated with the herb.
Mild Side Effects
Most studies evaluating chasteberry indicate it is well-tolerated by the majority of women. A small percentage of women report experiencing some mild side effects; however, these complaints are often similar to those who received a placebo. Minor adverse side effects include dry mouth, dizziness, mild gastrointestinal upset, headaches and fatigue.
Rare Side Effects
According to Wellness.com, rare occurrences of more serious side effects have been reported. Rare gastrointestinal side effects include diarrhea, heartburn, nausea and vomiting and gas. Some women have reported hair and skin side effects, including acne, eczema, rash, hives, itching and hair loss (alopecia). Heart and lung-related side effects have included rapid heart rate (tachycardia), palpitations and pulmonary edema (lung swelling) while rare hormonal side effects such as hot flashes, altered ovarian hormone levels, breast pain (mastalgia), menstrual cycle changes, fibroid growth and weight gain, menstrual bleeding, pelvic disease and vaginitis have also been reported. Other rare effects include vertigo, seizure, nosebleed, frequent urination and circulatory disorders.
Hormonal and Neurochemical Side Effects
Because chasteberry affects hormones, it may adversely affect women with hormone-sensitive conditions such as breast cancer. It should also be used cautiously by those taking birth control pills or those on hormone replacement therapy because of the risk of interaction and unknown side effects. Additionally, chasteberry is said to have dopaminergic effects, because it can affect the dopamine system in the brain. Dopamine is a neurotransmitter that has been linked to psychological mood disorders, as well as conditions such as Parkinson's disease. Research confirms that chasteberry binds directly with dopamine receptors. (See Reference 3) Those who are taking medications called dopamine antagonists (those that block dopamine receptors) or dopamine agonists (those that activate dopamine receptors) or Parkinson's patients who are taking medications like bromocriptine (Parlodel), metoclopramide (Reglan), selegiline, amantadine, or levodopa should exercise caution. Although no interactions have yet been reported, chasteberry has the potential to interfere with the functioning of these medications.
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