According to Drugs.com, Tri-Luma is used for the short-term treatment of darkening of the face (melasma). It may be used in combination with sunscreen or other preventative measures to limit sun exposure to the skin. Tri-Luma, according to Drugs.com, is comprised of topical corticosteroid, a depigmentation agent and keratolytic. How this medication is successful is not clearly understood, according to Drugs.com. As with any medication, Tri-Luma has the risk of side effects.
Common Topical Side Effects
The most common side effects of Tri-Luma, according to Drugs.com, occur at the application side of the cream. These effects are not considered serious unless they become persistent or overly bothersome. Such effects, listed by Drugs.com, include acne, numbness, tingling, redness, peeling, mild burning, irritation, stinging, dryness, itching, sensitivity to sunlight and warmth at the application site.
Serious Topical Side Effects
Serious side effects that occur at the application site should be reported to a doctor and Tri-Luma should be discontinued. Such effects, as reported by RxList.com, may include excessive hair growth at the site or nearby, gradual discoloration of the area as it turns bluish-black, inflamed hair follicles, inflammation near the mouth, or lightening of the skin at the application site. Drugs.com also warns of severe or persistent burning, redness, welling, blistering, oozing, crusting or irritation of the skin. If the skin becomes thin, softens or develops an unusual color, Drugs.com recommends the patient seek medical treatment.
Other Serious Side Effects
Trouble breathing; tightening of the chest; swelling of the mouth, face, lips or tongue are signs of severe allergic reaction, according to Drugs.com. Other serious concerns identfied by RxList.com include weakened muscles or unusual weight gain, especially in the face.
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