Fosamax (alendronate) is classed as a bisphosphonate prescribed for osteoporosis and Paget's disease. Mayo Clinic staff say bisphosphonates are "the treatment of choice" for Paget's disease, but cannot be taken if the patient has serious kidney disease. Osteoporosis and Paget's disease affect bone density and malformation of the bones, especially in women as they age. Bones can become misshapen, brittle and break easily. Fosamax can help slow the progression of these diseases. As with all medications, Fosamax has side effects, some of which can be severe.
Allergic Reactions
Allergic reactions to Fosamax can be severe and medical attention needs to be sought immediately if the patient experiences difficulty breathing, chest tightening, trouble swallowing, starts to vomit blood or have bloody stools. Drugs.com advises immediate medical intervention for any of these serious side effects.
Other Serious Reactions
Other allergic reactions to Fosamax include facial swelling, itching and skin rashes. Although these side effects may not appear serious, they indicate allergic reactions that may be more serious. Drugs.com states that other serious allergic reactions could include mouth sores, skin peeling and blisters.
Bone and Muscle Pain
Bone and muscle pain may result from taking Fosamax and may indicate a rare jaw bone disease called osteonecrosis of the jaw. Mayo Clinic staff advise seeking immediate medical attention if bone pain, muscle pain or swelling of the jaw or joints results from taking Fosamax.



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