According to MedlinePlus, myelofibrosis refers to a serious condition where your bone marrow is replaced with scar tissue. Your bone marrow is located in the inner core of your bones and is responsible for producing the many blood cells in your body. The cause of myelofibrosis is unclear, but there are a few symptoms that characterize it.
Anemia
According to the Merck Manual, myelofibrosis can lead to a blood condition called anemia, a condition of low red blood cells. In myelofibrosis, cells called fibroblasts make an excessive amount of fibrous connective tissue. This connective tissue interferes with cell production and results in decreased red blood cells. You may experience fatigue, weakness, weight loss and night sweats when you suffer from anemia.
Bruising and Bleeding
MedlinePlus states that myelofibrosis can lead to bruising and easy bleeding. In myelofibrosis, decreased levels of blood cells called platelets result. This is medically known as thrombocytopenia. Common symptoms of thrombocytopenia include bruising and easy bleeding.
Enlarged Liver and Spleen
According to the Merck Manual, your liver and spleen take over the role of your bone marrow and try to build new blood cells. This contributes to their enlargement. Symptoms of enlarged liver include portal hypertension (high blood pressure in the veins that supply your liver with blood) and esophageal varices (bleeding of the blood vessels in your esophagus). Some symptoms of an enlarged spleen include left-sided stomach pain, anemia and fatigue.
Other Symptoms
MedlinePlus states that you may also experience bone pain and difficulty breathing when you have myelofibrosis. Due to the fluctuations in white blood cell levels (which help fight infection), you are susceptible to infections. Call your doctor when you experience these symptoms.
