Creatine naturally exists in the body, which uses it to create a substance that provides the muscles with energy. For this reason, it is a popular supplement for athletes, particularly for activities requiring short, intense bursts of energy. Like many supplements, creatine might cause some negative effects, particularly when used in specific instances and daily use makes them more likely. Talk to your doctor about proper use of creatine before taking it.
General Safety
When used appropriately, creatine appears a generally safe supplement for the average person. The University of Pittsburgh Medical Center reports that studies examining its use up to periods of five years found no significant adverse effects. Anytime you plan on using a supplement long-term, always talk to your doctor.
Decreased Kidney Function
If you have normal renal function, using creatine on a regular basis in the normally suggested doses -- about 2 grams to 5 grams a day -- will probably not pose any risk to your kidneys, according to a review of studies appearing in a 2004 issue of ‘’The Journal of Herbal Pharmacotherapy.’’ The article notes an increased risk of kidney damage if you have kidney disease or if you take drugs that carry a risk of toxicity to the kidneys.
Interactions
The University of Maryland Medical Center site reports using creatine along with the acid-reducing medication cimetidine, the gout medication probenicid or diuretics might increase the risk of kidney damage. Taking creatine along with caffeine or diuretics can increase the risk of dehydration.
Other Safety Concerns
Possible side effects from creatine, aside from kidney damage, include high blood pressure, liver damage, weight gain, gastrointestinal upset, dizziness and muscle cramps. The University of Pittsburgh Medical Center also notes reports of creatine causing abnormal heart rhythms.
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