Nitric oxide is one of the most vital gases in your body, and is needed for a variety of uses. Nitric oxide expands the diameter of blood vessels, which allows a higher concentration of oxygen-rich blood cells to enter tissues. Because of this action, athletes and those with artery plaque buildup rely on this compound to enhance muscle definition and prevent the narrowing of artery walls. L-arginine is a semiessential amino acid, which means your body naturally produces this compound, but occasional supplementation can be required or used. This amino acid plays a direct role in producing nitric oxide. Discuss use of L-arginine with your physician if you plan to supplement or eat more foods that contain this amino acid.
Nitric Oxide Formation
Nitric oxide is manufactured by an enzyme known as nitric oxide synthase, NOS, which is derived from L-arginine. Several types of NOS control formation of nitric oxide throughout your body. These forms are defined as endothelial NOS, which is a thin layer of cells lining the interior of blood vessel walls, and neural NOS, which acts as a neurotransmitter in your brain. Under normal circumstances, nitric oxide is continually made by endothelial and neural enzymes. Because nitric oxide has a very short lifespan in your body, a continual supply must be made. Thus, L-arginine is constantly called upon to support formation of this gas.
Effects of Nitric Oxide and L-Arginine
Nitric oxide is responsible for relaxing muscles, inhibiting platelet aggregation and having an anti-inflammatory effect. In your brain, nitric oxide is responsible for supporting receptor sites for bradykinin, adenosine and substance P, which is the pain receptor site. MayoClinic.com states L-arginine may play an important role in treating vasodilation ailments, such as erectile dysfunction, heart disease and headaches caused by blood vessel inflammation.
L-Arginine Supplementation
At time of publication, there is no standard dosage of L-arginine specifically for nitric oxide synthesis, or signaling. The therapeutic dosage of supplementation ranges from 400 to 6,000 mg per day. You may consume this semiessential amino acid through capsules or in dietary sources. Pecans, Brazil nuts, chocolate, chicken, brown rice, gelatin, almonds, sunflower seeds and dairy products are high sources of L-arginine. Talk with your doctor regarding L-arginine supplementation to ensure its safety as well as to obtain a recommended daily dosage.
Causes of Abnormal NO Levels
Certain diseases and conditions are associated with a low level of nitric oxide. Even if your body is producing ample amounts of this compound, ailments may hinder the bioavailability of NO, meaning your body is unable to effectively utilize this gas. Conditions such as high blood pressure, heart failure, Type 1 and Type 2 diabetes, obesity and cigarette smoking all affect your ability to produce and use nitric oxide.
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