Everyone feels fatigued from time to time. While there are a number of causes for fatigue, certain nutritional deficits, such as low levels of glutamine, may also play a role. Research shows, in fact, that rather than cause fatigue, glutamine may actually help reduce symptoms of fatigue, particularly in athletes. Consult your doctor before using any dietary supplements.
About Glutamine
Glutamine is one of 20 amino acids manufactured by your body. Glutamine, formed from another amino acid, known as glutamic acid, is found in your brain and muscles. It plays a key role in many biological processes, including acting as fuel for your cells and helping maintain immune system functioning. If you engage in heavy exercise, or suffer from trauma or infections, your glutamine levels can quickly become depleted, according to Tufts Medical Center. Low levels of glutamine can cause fatigue or a weakened immune system. Glutamine supplements may help improve these conditions.
Causes of Fatigue
Fatigue is different from feeling sleepy. When you feel fatigued, you experience a lack of energy and a lack of motivation, although you may also feel tired and sleepy, according to the Mayo Clinic. During times of stress, intense physical exertion, infections or illness, you may experience increased feelings of fatigue. Prolonged exposure to these conditions can reduce glutamine levels, which your body requires for fuel. However, certain medical conditions, like chronic fatigue syndrome, fibromyalgia, depression and anxiety, can also cause fatigue. Alcohol or drug abuse, lack of sleep, inactivity and poor nutrition may also be responsible for feelings of fatigue. In certain cases, glutamine supplementation can help decrease fatigue and boost your energy levels.
Clinical Evidence
In her book, "Prescription for Nutritional Healing," nutritionist Phyllis A. Balch states that l-glutamine is helpful for reducing fatigue and improving mental functioning. However, most research on glutamine's effects on fatigue has been in relation to athletes engaged in intense physical activity. A clinical review published in 1999 in the "Canadian Journal of Applied Physiology," suggests that glutamine may be a beneficial supplement for athletes who engage in strenuous physical activity, by helping reduce infections and increase energy levels. More studies are needed to evaluate glutamine's effects on fatigue in the general population.
Considerations
While glutamine appears to have an effect on fatigue, you should not attempt to self-diagnose your condition. If you suffer from extreme fatigue without an easily identifiable cause, consult your doctor, as this may be a sign of an underlying medical illness. Never use dietary supplements to self-treat your symptoms. Glutamine can interact with certain medications. If you choose to use glutamine, inform your doctor.
