Amyotrophic lateral sclerosis (ALS) is a progressive neuron disease that results in loss of motor control and other bodily functions. In combination with genetic factors, environmental pollutants like manganese have been investigated as possible causes of ALS. Learning about the nature of ALS and manganese poisoning can help you understand the similarities and differences between the two conditions.
Causes
While genetic risk factors have been identified in a minority of ALS patients, it is not currently known what causes most cases of ALS. Exposures to toxins like heavy metals, pesticides and minerals like manganese have been explored as possible causes of the disease. According to the Amyotrophic Lateral Sclerosis Association, no single toxin has been conclusively linked with the condition. Manganese poisoning is caused by chronic or acute exposure to the trace mineral manganese, which sometimes occurs in professions like welding or mining.
Signs and Symptoms
While manganese poisoning and ALS share a few common symptoms, the two conditions are also different in many ways. A study by Tameko Kihira in the August 2004 edition of the "Japan Medical Association Journal" states that manganese poisoning, like ALS, can cause neurological symptoms such as gait disturbances and akinesia. Additional symptoms of manganese poisoning like behavioral changes and hallucinations are not typical of ALS, which does not affect cognitive or psychological functioning. Other symptoms not seen in most ALS patients include emotional hypersensitivity and changes in vocal tone
Prevention/Treatment
If ALS is suspected, your doctor may perform an MRI, nerve conduction test or blood and breathing exams to aid in diagnosis, according to Medline Plus. Currently, there is no cure for ALS. The medication Riluzole can slow the progression of the disease, while other medications may be prescribed to alleviate symptoms like muscle spasticity. Treatment for manganese poisoning usually involves chelation therapy to remove manganese from the body and levodopa to treat movement-related symptoms. Even with treatment, symptoms of manganese poisoning are often irreversible.
Warning
Both ALS and manganese poisoning are serious conditions that require medical treatment. If you experience symptoms like muscle rigidity or difficulty swallowing, make an appointment to see your doctor right away. Since the symptoms of ALS and manganese poisoning can overlap with those of other diseases, obtaining a proper diagnosis is necessary before an effective treatment can be found.
