Lysinuric protein intolerance is a rare disorder that results in an inability to digest protein, according to the Genetics Home Reference Library. Problems with protein digestion can also be caused by a lack of stomach acid, especially in people who take strong antiacids on a regular basis. Because protein is an essential nutrient, the inability to digest it will result in a number of health problems.
Early Symptoms
The first few symptoms of lysinuric protein intolerance show as soon as a baby stops breastfeeding. This is because breast milk is low in protein and thus it causes no problem for the baby. Once the child switches over to other protein-rich foods, such as formula, he might experience diarrhea and vomiting. If he continues to be force-fed protein, he might slip into a coma, according to Dr. Gianfranco Sebastio, associate professor of pediatrics at Federico II University in Italy.
Muscle Wasting
Because protein is essential for the development of muscles, an inability to digest protein can cause serious muscle wasting. An inability to digest protein can lead to muscle hypotonia, a condition in which the muscle loses tone and strength. As a result, the hip and neck are more prone to dislocations, according to the Children’s Hospital Boston. In children, muscle hypotonia can cause difficulty breathing and feeding, since both require the use of muscles.
Bone Problems
An inability to process protein leads to poor growth and short stature, according to the Genetics Home Reference Library. In time, this will lead to brittle bones and the development of osteoporosis, sometimes during childhood. The amino acid lysine –found primarily in protein-rich foods-- is essential to the growth, development and health of bones, tendons and connective tissue in general. People who can’t digest protein can’t assimilate this amino acid, thereby leading to a deficiency.
Other Problems
Over time, both the lungs and the kidneys will suffer from lack of protein. In serious cases, it can lead to end-stage renal disease as the kidneys become unable to filter enough toxins to keep the body healthy. Since protein is essential to the health of the circulatory system, lack of it in the body might lead to hypochromic anemia and other hematologic abnormalities. People who have trouble digesting protein can also experience acute pancreatitis and intellectual disability..
References
- News With Views; The Health Hazards of Blocking Acid Production by the Stomach; Dr. James Howenstine, MD.; December 2004
- Genetics Home Reference Library: Lysinuric Protein Intolerance
- Creators.com; Long-Term Use of Acid-Suppressing Drugs May Pose Significant Health Risks; Dr. Rallie McAllister; 2009
- Patient UK: Acid Reflux and Oesophagitis
- U.S. National Library of Medicine; Lysinuric Protein Intolerance; Gianfranco Sebastio, M.D.; May 2011
- Children's Hospital Boston: Muscle Weakness (Hypotonia)
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