Biotin, or vitamin B7 or H, is a water-soluble vitamin that metabolizes carbohydrates and amino acids. The vitamin plays a key role in converting nutrients into energy. Although biotin is well tolerated when taken in recommended dosages, certain side effects may occur when taking more than 10 mg of the vitamin per day. Consult your physician before taking biotin to discuss the appropriate amount for your condition.
Allergic Reaction
Although biotin supplements are generally considered safe for most people, excess amounts of the vitamin may cause an allergic reaction. Symptoms of a severe allergic reaction include throat closure, difficulty breathing, chest pain or hives. These symptoms may indicate anaphylaxis, a serious medical condition that requires immediate medical attention. Left untreated, a serious allergic reaction may cause loss of consciousness or death. Consult your physician before using biotin if you are allergic to any dyes, preservatives or foods.
Eosinophilic Pleuropericardial Effusion
A rare medical condition known as eosinophilic pleuropericardial effusion has been linked to high doses of biotin in one reported case. An article published in the April 2001 issue of "The Annals of Pharmacotherapy" reports that a 76-year-old woman experienced the rare condition after taking 10,000 mcg of biotin and 300 mg of pantothenic for two months. An eosinophilic pleuropericardial effusion is a severe health condition that occurs when air and blood enter the pleural cavity surrounding the lungs, which causes a major pulmonary infection.
Blood Glucose Levels
Because biotin is needed for the formation of glucose and fatty acids in the body, potent levels of the vitamin may affect blood glucose levels. If you are diabetic, consult your physician before using biotin supplements.
Skin Irritation
High doses or prolonged use of biotin might cause skin irritation. Extended use of high levels of the vitamin can aggravate existing skin infections, such as eczema, or cause a rash. If you experience hives, itchy rash or any other type of skin irritation, stop taking the supplement and consult your physician.
Food Interactions
According to the National Institutes of Health, raw or uncooked egg whites contain a substance that affects the absorption of biotin in the intestines. Daily consumption of two or more raw egg whites might cause severe biotin deficiency. Symptoms of biotin deficiency include a scaly rash on the face or genital area and hair loss.
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