Health providers prescribe escitalopram, sold under the brand name of Lexapro, to treat depression and generalized anxiety disorder. Melatonin is a hormone primarily used to treat insomnia, although the hormone may be helpful with other conditions as well. Both Lexapro and melatonin may interact with other medications, so it is important to consult your physician about which combinations work best for your situation.
Lexapro
Lexapro is in the class of drugs known as selective serotonin reuptake inhibitors, or SSRIs. These drugs target serotonin receptors in the brain, allowing more serotonin to remain in the gap between nerve cells. A number of drugs can potentially interact with Lexapro. Interactions range from mild to severe. If you are prescribed Lexapro, you should talk to your doctor or pharmacist before taking any over-the-counter medication. Ensure that your physician knows about any other prescribed medications you take.
Lexapro Interactions
Some other psychiatric medication can interact with Lexapro. Monoamine oxidase inhibitors -- MAOIs, St. John's wort and lithium can cause serotonin syndrome when taken with Lexapro. Other medications that may interact include warfarin, triptans, tramadol, pimozide, metoprolol. linezolid, ketoconazole or cimetidine. Taking these medications with Lexapro can increase or decrease their effectiveness and may potentially cause more side effects. Over-the-counter medications such as nonsteroidal anti-inflammatory drugs and aspirin taken along with Lexapro can increase your chances of stomach bleeding.
Melatonin
Melatonin is a natural hormone that helps to regulate other hormones, including the body’s circadian rhythm. Melatonin helps to regulate female hormones. It slows down aging and contains antioxidants. Researchers have looked at melatonin for potential health benefits. According to the University of Maryland Medical Center, melatonin may be more effective than a placebo when treating jet lag. Other possible benefits of melatonin include helping with sleep problems related to menopause and benzodiazepine withdrawal. Women with breast cancer and men with prostate cancer often have lower levels of melatonin as well.
Melatonin Interactions
You can purchase melatonin supplements at drugstores. However, the supplements may interact with certain medications. Melatonin may reduce the effectiveness of antidepressants. Melatonin may also reduce the effectiveness of blood pressure medications and calcium channel blockers. Avoid taking melatonin if you are taking a blood thinner because melatonin may increase the risk of bleeding. Melatonin can also cause steroids and other medications designed to suppress the immune system to lose their effectiveness.
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