According to YourPlasticSurgeryGuide.com, Restylane injections were approved by the FDA in 2003 for the treatment of facial wrinkles. The Mayo Clinic states that cosmetic surgeons have been using Restylane since 1996 to help soften moderate-to-severe wrinkles. The effects of this facial filler typically last at least six months. Although most of the side effects are considered to be mild, in rare cases patients experience more serious adverse reactions.
Swelling and Infection
After undergoing Restylane injections, there may be significant swelling and redness for up to three days in and around the treatment area. In some cases, people develop an infection or cold sore at the injection site. According to Restylane.com, while it's a rare occurrence, your doctor may inject the filler into a blood vessel. This can cause damage to the skin.
Pain and Bruising
Other common adverse responses during the first couple of days of recovery are pain and discoloration. The most frequent side effect from Restylane injection is bruising. According to a ABoardCertifiedPlasticSurgeonResource.com, bruising occurs in approximately 20 percent of all patients.
The Mayo Clinic says patients are generally instructed to abstain from aspirin, non-steroidal and anti-inflammatory drugs, as well as herbal supplements or high doses of vitamin E for three weeks prior to a Restylane injection. These substances may cause bruising or bleeding at the site of the injection.
The more serious reactions to Restylane usually occur in patients with hypersensitive skin. According to a ABoardCertifiedPlasticSurgeonResource.com, Restylane injections cause more pain than collagen wrinkle fillers because collagen injections involve an anesthetic.
Flu-Like Symptoms
In some cases, patients will have a physical reaction to Restylane injections. Symptoms may include headaches, nausea, abdominal cramps and other flu-related complaints.
Muscle Weakness
In rare instants, Relstylane patients may develop muscle weakness which typically goes away in a few days. However, this unlikely symptom can persist for several months following an injection.



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