Amyloidosis is a rare illness with multiple recognizable symptoms. It occurs when the bone marrow produces unusual antibodies. These antibodies, called amyloid proteins, build up first in the bloodstream and then become deposited into tissues and organs. Eventually, the organs begin to suffer damage due to presence of the amyloid proteins. Typical areas affected by amyloidosis include the heart, kidneys, nervous system, spleen, gastrointestinal tract and liver. Any organ can be damaged by amyloidosis.
As with most diseases, early intervention brings a likelihood of a better treatment response.
Skin Lesions
According to an article published in "Dermatology Online Journal," skin lesions are frequently the earlies sign of amyloidosis. These lesions may manifest as a red area on the skin that resembles a red bruise or red dots. This type of lesion is frequently found in skin folds, such as the eyelids, and often occurs spontaneously after coughing or a similar action. A second type of lesion looks like a waxy, yellow plaque or nodule that may become red. It is frequently found on a bend in the skin or on the face or gums. The nails may begin to look unhealthy and seem unusually white or brittle.
Enlarged Tongue
The tongue may become enlarged, a condition known as macroglossia. This may be barely noticeable and the first warning of it may simply be that the tongue feels different in the mouth.
Bilateral Carpal Tunnel Syndrome
According to a case study published in "Dermatology," carpal tunnel syndrome can be an early sign of amyloidosis. Bilateral carpal tunnel syndrome is especially suspicious and, if no occupational or recreational reason for it is present, testing for amyloidosis may be performed.
Swelling of the Ankles or Legs
Amyloidosis may affect the functioning of the heart muscle, leading to fluid accumulation in the ankles and eventually the legs and feet. This swelling, known as edema, may seem to occur over a matter of days or have a gradual onset.
Shortness of Breath
The person with amyloidosis may feel short of breath with minimal or no exertion. This is known as dyspnea and is also due to cardiac involvement.
Fatigue
Fatigue is another symptom of amyloidosis. The first sign noticed may be that the sufferer becomes tired easily and is resting more often than usual.
Poor Appetite and Weight Loss
Due to fluid accumulation around the gastrointestinal organs, the person with amyloidosis may develop a poor appetite. This may lead to noticeable weight loss.
Dizziness
The person with amyloidosis may become dizzy when he stands up quickly. This is known as postural hypotension and the sufferer must remember to stand slowly to avoid the possibility of falling or fainting.
