Mitotane is a chemotherapy medication used to treat adrenal cortical carcinoma (cancer of the adrenal gland). According to MedlinePlus, it is an antineoplastic agent that decreases the size of your adrenal tumor and stunts the growth of the fast-growing cancer cells. Usually, you will consume 2 to 6g of mitotane daily, in three to four doses, according to the National Library of Medicine. Depending upon the severity of your symptoms, your doctor may increase your mitotane dosage.
Common Side Effects
Drugs.com says that you may typically develop drowsiness, vertigo, a skin rash, nausea or diarrhea. It can also cause constipation, a poor appetite and fatigue. MedlinePlus says that mitotane can cause skin color changes and visual problems. Tell your doctor about these symptoms, especially if they continue for three or four days.
Harmful Side Effects
According to MedlinePlus, mitotane can cause harmful side effects, such as stomach pain, tachycardia (a fast heartbeat), chills, high fever and diaphoresis (sweating). It may also cause cold and clammy skin, unsteadiness, pain with urination, bloody urine and unintentional weight loss. Call your doctor immediately if these side effects emerge. She may decrease your dose of mitotane or switch you to another medication.
Other Concerns
You should avoid mitotane if you have a hypersensitivity to it. You can develop such life-threatening side effects as trouble breathing, hives or swelling of your face, lips, tongue and throat. Call 911 in the event that this occurs.
Avoid mitotane if you suffer from liver disease. Mitotane levels may increase in your body and cause the aforementioned effects.
The National Library of Medicine reports that chronic use of mitotane at high dosages can lead to brain damage. Your doctor should regularly monitor you, especially if you use mitotane for more than 2 years.
It is not known whether mitotane can adversely affect a pregnancy or contaminate breast milk. In any case, tell your doctor whether you are pregnant or intend to nurse your child.
Drugs.com indicates that you should tell your doctor if you are taking warfarin, spironolactone, any over-the-counter medications, vitamins or herbs. All of these can interact with mitotane and lead to the aforementioned side effects.
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