Orinase (tolbutamide) is a medication used to treat type II diabetes. According to MedlinePlus, Orinase reduces your blood sugar by prompting the pancreas to secrete insulin, a natural hormone in your body that regulates blood sugar levels. According to the National Library of Medicine, there is no set dose for Orinase treatment as it is dependent on your blood sugar levels.
Common Side Effects
According to MedlinePlus, Orinase's common side effect is hypoglycemia (low blood sugar). Symptoms of hypoglycemia include sweating, nervousness, dizziness, hunger and pale skin. It can also cause tremors, lightheadedness, irritability, headache and weakness. Other common hypoglycemic side effects include changes in behavior or mood, paresthesias (numbness or tingling) around the mouth and clumsy movements. Drugs.com says that Orinase can also cause heartburn, nausea, redness and a skin rash.
Serious Side Effects
Drugs.com says that Orinase can cause such harmful side effects as weakness, easy bleeding or bruising, dark urine, convulsions and confusion. It can also cause memory problems, poor appetite, jaundice (yellowing of the skin), hallucinations and unsteadiness. Other serious side effects include fever and fainting. Get immediate medical help when you have these side effects.
Other Side Effects
The National Library of Medicine says that Orinase can also cause leukopenia (low white blood cell counts) that make you prone to infection. It can also cause hyperglycemia. Symptoms of hyperglycemia include frequent urination, weakness, blurry vision, intense hunger and frequent urination. In severe cases, Orinase may cause loss of consciousness, seizures and confusion. Orinase can also cause a condition called diabetic ketoacidosis, which causes dry mouth, stomach pain, a fruity breath, loss of consciousness and stomach pain..
Miscellaneous Concerns
Inform your doctor if you are breast feeding or pregnant. It is not known whether Orinase can pass into your breast milk or to your unborn baby.
You should tell your doctor if you are taking such medications as isoniazid, warfarin, niacin, probenacid or prednisone. These drugs may interact with Orinase and cause the aforementioned side effects.
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