Arthritis and Enbrel
Enbrel (etanercept) is used to treat multiple types of arthritis, each affecting different joints. Enbrel effectively treats rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondilytis and psoriatic arthritis. It is one of the few medications that works well for many types of arthritis.
How Enbrel Works
In arthritis, there is a problem with auto-immunity, that is, the body has difficulty recognizing the joint lining as part of itself. Thus, antibody is produced against components of the joint. These antibodies stimulate the production of chemicals (called cytokines) that cause inflammation. One such chemical, called tumor necrosis factor (TNF), binds to certain receptors on the surface of cells marking those cells as targets for destruction. This destruction is the basis of the ongoing pain, swelling and loss of function in arthritis.
Enbrel works on the cells of the joint to cover the receptors that binds TNF, protecting those joints from the effects of TNF. Sparing the cells leads to reduction of inflammation with reduced pain and swelling. Joint function and mobility is gradually restored in such cases.
Dosage/Considerations
Enbrel is a prescription medication used in both adults and children older than 2 years of age. It comes as a pre-filled, single-dose injection or multidose vials. There are usually strict directions of use.
The actions of Enbrel in blocking inflammation also block the body's response to infections. Therefore, Enbrel is not used when infections or fever are present. The development of infections or fever during the use of Enbrel warrants immediate discontinuation of treatment and a medical evaluation.
