Zaleplon Side Effects

Zaleplon is a medication used to manage insomnia. According to Drugs.com, zaleplon is a sedative hypnotic that balances neurotransmitters, or the chemicals in your brain, such as serotonin to help you fall asleep. Typically, you will take 10 mg of zaleplon before bedtime, the National Library of Medicine says. The dosage may be adjusted based on your weight.

Common Side Effects

Zaleplon can cause numerous common side effects. According to MedlinePlus, it can cause drowsiness, lightheadedness and dizziness. Lightheadedness is typically the result of a lack of blood reaching your brain. This can be due to hypotension (low blood pressure). Zaleplon can also cause a memory problems, headache, lack of coordination, a poor appetite, changes in your sense of smell, menstrual irregularities and paresthesias (numbness and tingling of your feet or hands).
In a placebo-controlled study of 569 patients receiving either 5 or 10 mg of zaleplon, the National Library of Medicine found that 30 percent had a headache, 3 percent developed menstrual irregularities and less than 1 percent had peripheral edema (swelling of the hands or feet). Fortunately, these side effects are all reversible. Talk to your physician when these symptoms remain for two to four days. A doctor can adjust your dose of zaleplon.

Serious Side Effects

Insomnia can sometimes mask serious psychiatric conditions or other medical problems. According to the National Library of Medicine, inform your physician when zaleplon does not work after seven to 10 days of treatment. Prolonged insomnia may lead to behaviors such as aggressiveness, hallucinations, depression and suicidal thinking. Discontinue zaleplon and call your doctor if you develop changes in your mental state.

Additional Concerns

Do not take zaleplon if you are allergic to it. An allergic reaction consists of difficulty breathing, rash, swelling of your tongue, throat or face, and hives.
Avoid taking zaleplon if you suffer from liver or lung disease, have a history of depression or suicidal thoughts, or a history of alcohol or drug abuse, Drugs.com says. Zaleplon can exacerbate these conditions.
It is unclear whether zaleplon can harm your baby in pregnancy. Notify your doctor when you become pregnant. Zaleplon passes into breast milk, so tell your doctor if you are nursing. He will give you a safer medication that doesn't affect your baby.
Avoid combining zaleplon with such medicines as cimetidine, promethazine, erythromycin and imaprine, MedlinePlus says. The combination of zaleplon with these medications can cause the aforementioned side effects. Zaleplon can also be habit-forming, so be sure to follow all instructions as outlined by your doctor.

References

Article reviewed by Cece Nash Last updated on: Jan 2, 2010

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