Also known under its generic name pantoprazole, Protonix is used to treat conditions where the stomach produces too much acid, leading to irritation and ultimately erosion of the esophagus lining. The most prevalent side effects of Protonix use are mild and manageable. There are some long-term concerns associated with Protonix use, however, which are worth noting and discussing further with your doctor prior to beginning any Protonix prescription.
Vitamin B-12 Deficiency
Long-term treatment with Protonix may make it harder for your body to absorb vitamin B-12, according to drugs.com. This is a common occurrence with all medications which work to suppress stomach acids, and according to rxlist.com is more likely to occur when taken daily for more than three years. A B-12 deficiency can result in lethargy and exhaustion, together with shortness of breath and an increased heart rate. Although B-12 deficiency occurs gradually and only with prolonged use of Protonix.
Stomach Problems
The most common side effects of Protonix use are mild and involve the stomach, according to rxlist.com. They include nausea, vomiting, gas pain, flatulence and diarrhea. It is not uncommon for a headache to accompany these symptoms or to occur in their absence.
Stomach Cancer
Both rxlist.com and drugs.com refer to animal studies performed to evaluate any additional side effects. Both sites point out that rats who were given high doses of Protonix over a long period of time eventually developed stomach cancers or benign tumors and polyps. It is not known if this effect can occur in humans taking Protonix, although it should be noted that most humans take lower doses of Protonix than those given to the laboratory rats.
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