Psychotic depression, also known as major depression with psychotic features, refers to a debilitating mental illness in which you experience symptoms of depression and psychosis (reduced contact with reality), according to Medline Plus.
Symptoms
According to the "New York Times", symptoms of psychotic depression include continual sadness and hearing voices that criticize and tell you what to do. For example, you may hear a voice saying you are not good enough and should kill yourself. These symptoms are dangerous and require immediate attention.
Cause
According to Medline Plus, a family history of depression and psychosis can lead to this condition. The exact cause for psychotic depression is unknown.
Diagnosis
According to the "New York Times", psychotic depression is diagnosed through a psychiatric evaluation. The patient is interviewed using such screening questionnaires as the Beck Depression Inventory or the Hamilton Rating Scale. It is important to rule out grief and loneliness because they can be mistaken for forms of depression. Other medical conditions should be ruled out, so a physical exam and laboratory tests should be obtained, according to Medline Plus.
Treatment
According to Medline Plus, treatments for psychotic depression include taking antidepressants and antipsychotic medications. Electroconvulsive therapy is another possible option. This involves triggering seizures in the brain to treat psychotic depression.
Complications
Possible complications of psychotic depression include suicide, poor health, divorce, unemployment, and alcohol or drug abuse, according to the "New York Times".


