Running on a treadmill is quite different than running outside in that running on a treadmill does not require forward movement. Because treadmill running only affects vertical displacement, treadmill runners tend to wear more heavily on the heels of the shoe. Many of the top running shoe companies are making shoes designed specifically for running on the treadmill, which include more cushioning in the heel.
Asics Gel Treadmill
The Asics Gel-Treadmill shoe has more cushioning in the heel, particularly on the outside, as treadmill runners tend to place more pressure on the lateral heel. Additionally, treadmill runners tend not to place as much pressure on the toes, therefore, Asics limited the amount of gel in the toes to help make the shoes lighter. Finally, according to Asicsamerica.com (the maker's website), there are vents in the sole to increase circulation, and an "Impact Guiding System" that encourages natural gait.
Reebok
Lovetoknow.com recommends a trio from Reebok. The Trinity KFS (KFS stands for "KineticFit System") has plenty of traction and provides support and flexibility. The Cushioning IV has lots of cushioning, hence the name, and has lots of mesh to help keep the foot cool. The Ultra KFS, much like the Cushioning IV, has ample cushioning in the sock liner and heel, which Reebok says will "soften the impact, allowing the runner to go for miles and miles."
Nike
A couple of Nike shoes are also recommended to help improve running on a treadmill. The Nike Air Equalon has an encapsulated heel and a "Zoom Air" unit, both of which provide lots of cushioning. Nike says the Air Equalon is a great shoe for those who overpronate (foot rolls inwards). The Air Max Moto was designed for distance runners who slightly underpronate or slightly overpronate; it is also built a little wider in the forefoot to provide comfort during a run.



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