Zetia (Ezetimibe), first approved by the Food and Drug Administration in 2002, is an anti-hyperlipidemic drug, prescribed to lower cholesterol levels. It works by blocking the absorption of cholesterol in the small intestine. It is used alone or in conjunction with statins when cholesterol levels are not controlled by statins alone. While clinical studies have proven Zetia effective at lowering cholesterol, there may be long-term side effects associated with its use.
Myopathy
Myopathy, which is mild muscle pain, is most often associated with Zetia taken in combination with a statin. Watch out for any increase in pain.
Rhabdomyolysis
Rhabdomyolysis is a disease which results in the destruction or degeneration of skeletal muscle tissue. Symptoms of rhabdomyolysis may include general pain and weakness, muscle pain and weakness, fatigue, and darkened urine color. Left unchecked, the disease can lead to kidney failure and death. Your doctor can monitor your for this condition by giving you a creatine phosphokinase test, which measures the levels of enzymes in skeletal tissue.
Liver Problems
Liver enzymes may become elevated in a small percentage of patients who take Zetia, particularly if it is taken in combination with a statin. Liver enzymes should be monitored by blood tests, which detect the levels of these enymes. Elevated levels of these enzymes are reversible once the drug is discontinued. Unchecked levels of liver enzymes may result in liver failure. Any patients who suffer from active or chronic liver disease should not take Zetia.
Short-Term Side Effects
Several short-term side effects are also associated with Zetia. These include diarrhea, mild fatigue, nausea, dizziness and headache. Allergic reactions are also possible, which include hives or a rash, or swelling of the face, lips, tongue or throat. Allergic reactions may require immediate treatment. Additionally, Zetia may be associated with gallstones or inflammation of the gallbladder. Patients should report any such symptoms to their doctor.
Member Comments