The Effects Of Mebendazole

Mebendazole is a prescription medication available as a chewable 100mg tablet and an oral liquid. It is indicated for the treatment of worm infestation and is effective against pinworm, roundworm, American hookworm, common hookworm and whipworm. According to the 2010 Lippincott's Nursing Drug Guide, typically prescribed dosages are 100mg, one time, to eradicate pinworm and 100mg twice a day for three days to eradicate the other worms.

Effects on Worms in the Body

Mebendazole works by not allowing the worm's body to form a part of its cells known as microtubules. This causes the worm to not be able to use glucose. The worm then uses all of its available glycogen (how glucose is stored in the body for energy), and it cannot reproduce or survive.

Effects on Humans

Mebendazole can have effects on the human body. These include nausea, abdominal pain, diarrhea, skin itching, hair loss, headache, rash, tiredness, sore throat, weakness, vomiting and dizziness. According to Drugs.com, the abdominal pain and diarrhea are worse if a large amount of worms is present in the gastrointestinal tract. Other side effects include fever and, rarely, convulsions. Effects on the blood and liver can occur if the drug is taken for a prolonged period of time. Drugs.com states that a hypersensitivity reaction, manifested by hives, rash and swelling of the face, mouth, tongue or throat, has occurred rarely.

Considerations

Drugs.com states that pregnant women should not take mebendazole. It is not known if mebendazole is excreted in breast milk. The medication has not been thoroughly studied for use in children under age 2 or the elderly. According to the Mayo Clinic, if you suffer from liver disease, ulcerative colitis or Crohn's disease, you should consult your doctor prior to taking the medication. The Mayo Clinic recommends the drug be taken along with food, and that fatty food is best. When pinworms are present, the entire household should be treated. Thorough handwashing must be performed, and bed linens, underwear and night clothing must be washed daily. Any toilets used must be washed daily as well. Be aware that the course of medication may have to be repeated to completely eradicate the worms.
If you have a whipworm or pinworm infestation, you may be anemic. If so, your physician may order iron medication after the worm eradication. This may continue for six months or until your red blood cell count returns to normal.