Augmentin 875 is a combination antibiotic containing the penicillin derivative amoxicillin and clavulanate potassium (a form of clavulanic acid). It is prescribed to treat bacterial processes such as sinus and ear infections, urinary and respiratory tract infections, and skin and tissue infections. The clavulanate chemical provides an edge against many drug-resistant bacteria, which have mutated and no longer respond to penicillin and other antibiotics. Side effects, however, were found during clinical trials.
Gastrointestinal Effects
According to the Food and Drug Administration, most of the side effects found for Augmentin in the 875 mg dose are considered to be mild and temporary, and Augmentin usually is well-tolerated. The most common side effect documented was diarrhea, followed by nausea. Other side effects, which occurred less frequently, were gas, vomiting, stomach discomfort and abdominal cramping. These also were not viewed as serious and were not long-lasting.
Skin Effects
Skin side effects such as rashes or urticaria (hives) may also result from taking Augmentin. Antihistamines or corticosteroids typically manage such skin reactions if they occur, the FDA says.
Rare Effects
In rare instances, more serious side effects may occur, necessitating immediate medical attention. During the clinical trials, a rare effect of Augmentin in women was antibiotic-induced vaginitis, or inflammation of the vagina. Another rare reaction was a change in urine color, turning it darker, thus indicating potential urinary or renal problems. Additionally, persistent nausea and vomiting, abdominal pain and jaundice have been documented, with slightly elevated liver enzymes suggesting a liver work-up may be needed; along with these symptoms, blood or mucous may appear in the stool. Other rare yet possible side effects include coldlike symptoms, such as fever, lingering sore throat and headache. Some individuals have experienced central nervous system effects such as anxiety or confusion, dizziness and insomnia, as well as seizures. There is also the possibility that a patient who has no known allergies will be hypersensitive to penicillin drugs, which can produce serious and life-threatening allergic reactions.
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