Diovan (valsartan)--one of the first angiotensin II receptor-blocker (ARB) drugs marketed for the treatment of high blood pressure--and Hydrochlorothiazide (HCT), a thiazide diuretic (water pill) long used for the treatment of high blood pressure and lower leg swelling, have been combined into one tablet: Diovan HCT. According to "The Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure," thiazides (such as HCT) remain the drug of choice for the initial treatment of high blood pressure. Most patients require at least two drugs to achieve adequate blood pressure control, so this combination offers the convenience of a simplified treatment regimen.
Several Infrequent Side Effects
According to the article "Angiotensin-II Receptor Antagonists: Their Place in Therapy" in the June 1999 American Family Physician, dizziness may occur in 2 percent to 4 percent of patients taking Diovan alone. Dizziness increases to nearly 6 percent in patients taking Diovan HCT, which is related to the potency of both medications. For this reason, Diovan HCT is started at a low dose and gradually increased as tolerated.
Constipation, dehydration, headache, nasal and throat irritation, dry skin, itching and light sensitivity can infrequently occur when taking Diovan HCT, and should be reported to your physician.
Abnormal Potassium Levels
Hyperkalemia (elevated blood levels of potassium) can occur in patients taking Diovan; hypokalemia (decreased blood levels of potassium) is known to occur with HCT alone. Many drugs, including nonsteroidal anti-inflammatory drugs such as ibuprofen, as well as potassium and herbal supplements, can also affect the blood potassium level when taken along with Diovan HCT. Your physician should routinely monitor your potassium level and kidney function if you're taking this medication.
Gout
Gout, an inflammatory condition related to elevated uric acid levels in the blood, is associated with diuretic use and is seen in patients taking Diovan HCT. According to "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure," gout was rarely reported with HCT doses less than 50mg.
Member Comments