A progesterone injection is a hormone available by prescription that is injected into the muscle. This medication is for patients who are not menstruating but should be. It is also for treatment of abnormal bleeding from the uterus and overgrowth of the uterine lining. It is often prescribed for other uses, such as infertility treatment. This medication may be administered by a medical professional but is often administered by the patient or a surrogate of her choosing after sufficient training.
Menstrual Changes
As expected, progesterone affects the menstrual cycle. Some unwanted side effects may include bleeding or spotting mid-cycle, erosion of the cervix, a change in the secretions from the cervix and a change in the amount of blood lost during the period.
Breast Tenderness
The breasts may become tender or sore, and milk may leak from the breasts.
Weight Change
Women who are taking progesterone therapy often experience a change in their weight. For some women, weight is lost while others put on extra weight.
Abdominal Cramping
This medication can cause abdominal cramps, similar to those that can occur prior to, or during, menstruation. The abdomen may feel bloated and constipation or diarrhea may be present.
Fever
Some patients develop a mild fever when taking progesterone. Also, sensitivity to light or dizziness can occur.
Depression
Depression may develop when taking this medication for several months. Drugs.com reports that some women complain of difficulty sleeping and excessive sleepiness as well.
Allergic Reaction
An allergic or hypersensitivity reaction can occur from taking progesterone injection. This may manifest as rash, hives, itching and swelling of the face, mouth, tongue or throat. Swelling of the throat may become life-threatening as it can make breathing difficult or impossible. Also, the allergic reaction can worsen into allergic shock. Emergency medical treatment must be sought for a severe allergic reaction.
Pain at the Injection Site
Pain may develop at the injection site. According to Drugs.com, this may be accompanied by redness or irritation. The site of the injection should be changed from one shot to the next. Discuss unusual or continuing pain or irritation with the physician.
Blood Clot
A rare but serious side effect of progesterone injections is a blood clot. This can occur in the leg or the eye or it can travel to the brain or lungs. Patients should be alert for swelling and pain in one leg, vision problems affecting one eye, numbness of one side of the body or sudden difficulty breathing. Other symptoms may also indicate a blood clot. The possibility of this side effect should be discussed with the physician for specific instructions.
References
- 2010 Lippincott's Nursing Drug Guide: Progesterone
- Drugs.com: Progesterone Professional Information
- Drugs.com: Progesterone Consumer Information
