Mucinex nasal sinus spray is an over-the-counter product used to treat nasal congestion. Its main ingredient, oxymetazoline, is a common ingredient in many over-the-counter nasal spray products. It is approved for use in people older than 6 for common causes of nasal congestion, such as seasonal allergies and colds. Despite being safe enough for over-the-counter use, Mucinex sinus spray can cause side effects
Nasal Side Effects
The most common side effects of Mucinex nasal spray are local effects in the nostrils: burning, itching, sneezing, dryness and extra discharge. The product contains inactive ingredients that may ease or worsen these effects. For example, camphor and menthol may relieve congestion but are irritating to the nasal skin lining; conversely, ingredients like propylene glycol and purified water may help soothe the irritated tissue.
Body Side Effects
In addition to local effects, Mucinex nasal spray may cause headache, dizziness and nervousness. A rare side effect is noticeable changes in heartbeat; though unlikely, this side effect may be serious and suggests the need for a doctor's visit.
Side Effects With Long-Term Use
Oxymetazoline may only be used short term (i.e., for a maximum of three days) as a nasal spray. Its primary mechanism is constriction of blood vessels in the nose; the constriction makes the airways open wide enough to feel less congested by reducing swelling. However, continued use of oxymetazoline causes the reverse, or dilation of vessels, to occur. This results in rebound congestion, which is often worse than the initial problem and is more difficult to treat. Nasal congestion that does not resolve after three days of treatment requires a visit to the doctor.


