Selective serotonin reuptake inhibitors, also called SSRIs, are prescription drugs indicated for depression and other psychiatric illnesses. When they are abruptly discontinued after being taken for six weeks or more, a discontinuation syndrome can begin one to three days later. Also referred to as SSRI withdrawal syndrome, this condition is usually mild and dissipates in a few days up to three weeks. Long-term use of SSRI's increases the odds of these symptoms, but this can be avoided by weaning off the drug slowly. Treatment for this condition involves either taking another dose of the drug and then weaning off it slowly or dealing with the individual withdrawal symptoms until they abate.
Dizziness
An article titled "SSRI Discontinuation Syndrome" published in Postgraduate Medicine reports that the most common symptom of this condition is dizziness. Various patients have described this as feeling unsteady, lightheaded, faint or as if the room is spinning. These symptoms generally worsen when the patient attempts to stand or move around.
Nausea
Nausea is another common sign of SSRI discontinuation syndrome. Other patients have complained of cramping, abdominal pain, diarrhea, vomiting and loss of appetite.
Headache
Mayo Clinic reports that headache is often noted during this time. It may be the only symptom noted, or it may be accompanied by muscle aches, muscle contractions, runny nose, chills, tremor or a feeling of having the flu.
Anxiety
Many patients report experiencing anxiety or crying as the discontinuation syndrome continues. Irritability, mood swings, aggression, nightmares and vivid dreams have also been noted, and difficulty sleeping is common. Some patients feel as though they cannot be still and pace or frequently stretch. Another complication of this syndrome is a temporary depressed mood which can concern the patient and physician that the patient's depression is returning. This mood lifts, however, as the syndrome wears off.
Tingling Skin
Abrupt discontinuation of SSRIs can cause a patient to experience tingling or numb-feeling skin. This may occur bilaterally, such as in both hands. The sensation of an electric shock going through part of the body may be felt. The patient may be frightened by these symptoms and wonder if he is suffering a stroke or other serious condition.
Excessive Tiredness
Excessive tiredness and not wanting to move around has been reported by patients. This may last throughout the days or weeks that the syndrome occurs. Blurry vision is another manifestation for some.
