An aspirin allergy is caused by a reaction to the drug itself and not a true allergy or immunological response to the medication. An aspirin allergy, or sensitivity to aspirin, can cause a life-threatening emergency, such as a severe asthma attack. Often, people with asthma suffer from aspirin sensitivity. The response to the medication or sensitivity usually occurs within a few hours of ingesting the medication and results in symptoms ranging from serious to mild. If you have had a reaction to aspirin, it is best to avoid NSAIDs, or non-steroidal anti-inflammatory medications, such as ibuprofen or naproxen sodium, since these have similar chemical makeups.
Hives
Hives are the first reaction you may exhibit. These are raised red bumps on your skin that can itch. An average hive can be at least 1/2 inch in size, according to the University of Virginia Health System, and can be quite irritating. Hives are usually all over your body's surface, from your scalp to your toes. Itchy skin, whether from hives or something else, is another response that indicates a possible sensitivity or that an allergic response has occurred.
Runny Nose and Swelling
A runny nose is another sign of an allergy, as the nasal passages are irritated from the allergen source. The inner mucosa, or mucous membranes, of the mouth also may be affected, meaning you may itch on the roof of the mouth. This can indicate a severe response to an allergen, such as aspirin. If you experience swelling of your lips, mouth or face, make a trip to the emergency room immediately, as this is a precursor to an anaphylactic response and can be life-threatening.
Breathing
Shortness of breath is yet another warning sign of a severe response to aspirin. This also warrants an immediate trip to the emergency room. Dialing 911 for this type of response may be necessary to transport the person immediately to the emergency room and receive help. People who have severe allergies should carry an auto-injection epinephrine pen for this reason, as a solvent before getting to the emergency room. An auto-injection epinephrine pen shoots epinephrine into the outer part of your thigh to help counteract the allergic reaction. Wheezing and coughing are other indications of this reaction and should not be taken lightly. These reactions are severe and life-threatening.
