Wrinkle treatments are commonly available without a prescription from drug stores and other retail outlets. The effectiveness of over-the-counter (OTC) wrinkle treatments isn't generally measured by scientific testing, although some wrinkle treatments may be able to reduce wrinkles. This primarily depends on the specific ingredients and length of time you use the wrinkle treatment, according to the Mayo Clinic.
Retinol
Retinol is one of the most common ingredients in OTC wrinkle treatments. It's one of the compounds known as vitamin A and is an antioxidant capable of neutralizing the free radicals that can cause wrinkles. Retinol isn't as strong as tretinoin, a vitamin A derivative that requires a prescription.
Hydroxy Acids
Hydroxy acids are a class of acids that are found in fruits that contain sugar. They treat wrinkles by removing the dead skin cells on the surface of the skin. This exfoliation promotes the growth of smoother, more evenly toned skin. Treatments with hydroxy acids will require you to wear sunscreen, since they make your skin more susceptible to sunburn.
Regulation
The Food and Drug Administration (FDA) classifies OTC wrinkle treatments as cosmetics rather than drugs. This means that the FDA generally doesn't require them to be tested for safety and effectiveness. However, the FDA may regulate the product more closely when it's advertised as a drug. It may also require warnings for specific ingredients.
Considerations
OTC wrinkle treatments may contain the same active ingredients as prescription treatments, but in lower doses. They will generally provide less effective and shorter-lasting results than their prescription counterparts. The cost of a wrinkle treatment has little bearing on its effectiveness. The most common side effects of OTC wrinkle treatments include burning, irritation, rashes and redness.
Regimen
The ultraviolet light from the sun is the primary cause of unnecessary aging in the skin. You should always wear sunscreen when you go outside, even during the winter. Many skin-care products include a sun protection factor (SPF) of 15 or more. Moisturizers can mask fine lines and wrinkles, although they can't actually prevent wrinkles from occurring. You should also refrain from smoking, which can cause your skin to wrinkle prematurely.



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