Oxycodone is a prescription medication approved for the treatment of moderate to severe pain. It is an opioid analgesic normally administered to people around-the-clock. Oxycodone works by blocking the pain pathways in the brain. This medication may be habit-forming and display physical dependence. Withdrawal symptoms will be severe if the drug is stopped suddenly. In cases where people take high doses due to addiction, there is more risk of developing severe withdrawal effects. It important to be tapered off the drug over time to keep withdrawal symptoms to a minimum.
Effects on the Eyes
After about six hours from the last dose of Oxycodone, withdrawal symptoms may become evident. One effect of stopping Oxycodone is mydriasis, which is the excessive dilatation of the pupils. Watery eyes, or lacrimation, are also present in many individuals. The development of physical dependence and the extent of withdrawal symptoms to the drug are related to the tolerance developed.
Fatigue
Fatigue and weakness may occur with Oxycodone withdrawal. In many individuals, insomnia has been reported and can further increase fatigue. Constant yawning has been noted in many individuals. Those going through Oxycodone withdrawal may also experience a runny nose.
Phsyical Effects
Oxycodone withdrawal has been linked with diaphoresis, or excessive sweating. Some people may get flu-like symptoms, such as fever, muscle and joint aches, and chills. Piloerection, which is goosebumps or gooseflesh, is also present. Vomiting and diarrhea may occur as well. Hostility, anxiety and confusion are other side effects of Oxycodone withdrawal. Hyperthermia is an increase in body temperature and will cause warmth or flushing in the face and hot dry skin. Hyperventilation, an increase in breathing rate, may also be present. Hyperthermia and hyperventilation may be signs of severe withdrawal symptoms and require immediate medical attention.
References
- "Drug Information Handbook 15th Edition"; Charles F. Lacy, RPh, PharmD, FCSHP, Lora L. Armstrong, RPh, PharmD, BCPS. et al; 2007
- "Pharmacotherapy: A Pathophysiologic Approach"; Joseph T. Dipiro, Robert L. Talbert, et al; 2008
- Drug Information Online: Oxycodone
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