Heartburn refers to an uncomfortable burning sensation in the chest that occurs as a result of stomach acid creeping up the digestive tract. According to the American Academy of Family Physicians, overeating, stress, pregnancy and certain foods like chocolate can worsen heartburn. Fortunately, over-the-counter and prescription medications exist to manage this burning sensation.
Aluminum Hydroxide and Magnesium Hydroxide
Aluminum hydroxide and magnesium hydroxide is a combination antacid drug used to manage heartburn, indigestion and stomach problems, the National Institutes of Health (NIH) says. This drug can also treat peptic ulcers, esophagitis (esophagus inflammation), gastritis (stomach flu) and a hiatal hernia, a condition in which the stomach actually pushes upward through the diaphragm (a respiratory muscle).
According to the NIH, common side effects are not expected when taking aluminum hydroxide and magnesium hydroxide. However, such serious symptoms as muscle weakness, diarrhea, constipation and a poor appetite can occur. Notify a doctor if these medicines cause these symptoms to develop.
Take such drugs as ketoconazole, isoniazid, itraconazole, ferrous sulfate, digoxin and diazepam two hours prior to taking aluminum hydroxide and magnesium hydroxide, the NIH says. The combination may decrease the effectiveness of these medications.
Aluminum hydroxide and magnesium hydroxide are available over-the-counter as a chewable tablet and as a liquid. Take the medication as indicated.
Magaldrate and Simethicone
Magaldrate and simethicone is also a combination drug used to neutralize the acid in the stomach, Drugs.com says. Its common effects include diarrhea, constipation and intestinal discomfort. Tell a doctor if magaldrate and simethicone's common effects remain for greater than seven days.
Black or bloody stools, vomiting, muscle weakness, nausea, a poor appetite and vomiting that appears to be of coffee grounds are just some of malgaldrate and simethicone's serious side effects. Notify a physician if magaldrate and simethicone causes these effects.
Magaldrate and simethicone is available over-the-counter as a liquid suspension that should be taken as indicated.
Metoclopramide
Metoclopramide is a medication used to treat heartburn for a short period of time, Drugs.com reports. Specifically, this medication speeds up gastric emptying by increasing the contractions of the muscles along the digestive system.
Metoclopramide's common effects include a headache, restlessness, diarrhea, vomiting, nausea, changes in the menstrual period, a headache and frequent urination. Metoclopramide also causes trouble sleeping, diarrhea and drowsiness. Contact a doctor if metoclopramide's side effects last for more than a week.
Metoclopramide's more serious effects include restlessness, tremors, depression, seizures, hallucinations, fluid retention, swelling, muscle stiffness, confusion, anxiety, agitation and fast or irregular heartbeats. Call a doctor if metoclopramide causes these effects.
Metoclopramide is a prescription liquid or tablet that should be taken as directed.


