The Combivent (ipratropium bromide and albuterol sulfate) inhaler---also known as the Combivent Inhalation Aerosol---is a prescription medication indicated for patients with chronic obstructive pulmonary disease (COPD) who continue to have symptoms despite the use of a regular aerosol bronchodilator. This medication should be used in conjunction with your COPD treatment per your doctor's instructions. Side effects associated with the Combivent inhaler can be serious and should be discussed with your doctor before you begin treatment.
Respiratory Irritation
During treatment with the Combivent inhaler, you can experience side effects associated with your respiratory system. Inhaled drug substances can irritate your throat or the lining of your airway passages, causing side effects that include cough or sore throat. Certain people experience nasal inflammation as a side effect of Combivent inhaler use, reports the Drugs website, a peer-reviewed online resource for currently marketed drug products.
Headache
After using the Combivent inhaler, you can develop a headache as a side effect of this medication. Headache symptoms are typically mild to moderate in severity and progressively subside with recurrent use of this medication.
Nausea
If you receive treatment with the Combivent inhaler, you can experience gastrointestinal side effects, such as upset stomach or nausea. Contact your doctor as soon as possible if you experience vomiting or severe stomach pain. Such side effects may be indicative of an allergic reaction to this medication.
Difficulty Sleeping
While receiving treating with the Combivent inhaler, you can develop sleep difficulties as a side effect of this medication. You may find it difficult to fall asleep or stay asleep after taking this medicine. This condition, called insomnia, can cause you to experience additional symptoms of tiredness and fatigue during treatment with the Combivent inhaler. If such symptoms significantly interfere with your ability to complete your daily activities, speak with your doctor to discuss symptom management options.
Increased Heart Rate
Using the Combivent inhaler can cause heart-related side effects to develop in some people. If you experience an increased heart rate (tachycardia) or decreased blood pressure, contact your doctor immediately. Heart-related side effects may also cause symptoms of dizziness, headache, chest pain or shortness of breath.



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