Physicians prescribe Lodine (etodolac) to reduce joint pain, stiffness, swelling and inflammation from osteoarthritis and rheumatoid arthritis. Lodine is a nonsteroidal anti-inflammatory drug (NSAID) that reduces the hormones that cause inflammation and pain with arthritis and other maladies. It gives symptomatic relief, but does not have curative powers for the targeted disease. Along with pain reduction, Lodine brings side effects for some who use the drug.
High Blood Pressure
Lodine can cause blood pressure elevation as one possible side effect. The Drugs.com website states you are at higher risk of a cardio-vascular event such as a heart attack or stroke when taking Lodine. The longer you use Lodine, the higher the risk of a heart or circulatory problem.
Gastrointestinal Bleeding
Taking Lodine can cause the patient to have stomach bleeding with either existing ulcers or by causing new stomach ulcers to form. The RxList.cim website states you are in danger of stomach or intestinal bleeding when taking Lodine. Perforation of the intestine or stomach may also be caused by Lodine as a side effect and can be fatal.
Stomach Upset
Lodine may cause stomach and digestive tract upset as a side effect. Mayo Clinic staff say Lodine may cause abdominal pain, gas, diarrhea, constipation or black, tarry stools. Other stomach problems that tend to be side effects of Lodine include belching, bloating, vomiting and stomach cramps.
Flu-Like Symptoms
Lodine can cause flu-like symptoms as a side effect. If you use Lodine, you may feel weak, tired, feverish or have chills. The Mayo Clinic website states taking Lodine may cause a sore throat, headache, diarrhea, itching, runny nose, swollen glands, indigestion, lower back pain and pale skin color. You may also have flu-like symptoms of trouble breathing, swallowing and feeling tired all the time.
Renal Problems
Taking Lodine can cause renal dysfunction and even renal failure as side effects. The RxList.com website advises against taking Lodine if you have any renal problems. Using Lodine for a long period of time can cause renal papillary necrosis, other renal injuries or even renal toxicity. This is especially dangerous with the elderly or with someone whose immune system is fragile. Once Lodine is stopped, full renal function is usually restored.



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