Benadryl (diphenhydramine) is an over-the-counter medication indicated for the treatment of symptoms caused by allergies, hay fever or the common cold. This medication can be orally administered in tablet, dissolving tablet, capsule, dissolving strip or liquid form. Speak with your doctor if you have any concerns regarding Benadryl side effects.
Drowsiness
You can experience extreme drowsiness as a side effect of taking Benadryl. Feelings of fatigue or sleepiness can occur shortly after taking a dose of Benadryl. Such side effects can significantly alter your reaction time and can interfere with your ability to drive a car or operate machinery.
Stomach Upset
After taking a dose of Benadryl, you can develop stomach-related side effects. You may experience nausea, vomiting, upset stomach or loss of appetite, explains Drugs.com, a peer-reviewed drug information website. Bowel movement changes, such as constipation or diarrhea, have also been experienced by certain people while taking this medication. Consider eating a small snack or meal before taking a dose of Benadryl to limit the occurrence of such side effects.
Headache
You may experience a headache as a side effect of Benadryl. Headache pain is typically mild to moderate in severity and progressively subsides after Benadryl treatment. Headache symptoms related to Benadryl use may also be accompanied by dizziness or lightheadedness.
Excitement
Certain people--especially children--can experience excitability as a side effect of taking Benadryl. Your child may appear to have more energy than usual or experience difficulty falling asleep as a result of this medication. Nervousness or anxiety can also develop in certain people after taking Benadryl.
Muscle Weakness
Certain people experience muscle weakness after taking a dose of Benadryl. This side effect may also contribute to additional symptoms, including fatigue.
Dry Mouth
Benadryl can cause your mouth, nasal passages or throat to develop a dry sensation. If this occurs, you may experience increased thirst, sneezing, nasal irritation or a sore throat.



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