Plavix, the brand name for clopidrogel, is an anti-platelet agent available as a prescription only. It prevents platelets from sticking together and forming clots; this will help to lower the risk of a heart attack or stroke. Plavix is used in individuals who have had a cardiac event, including a stroke and heart attack, and in individuals who have established angina (chest pain). It is also recommended in people who have peripheral arterial disease (PAD), which is characterized by poor circulation in the legs. Plavix is generally well-tolerated; however, some people experience complications from taking the medication.
Increased Bleeding
Plavix may increase bleeding time, or the time it takes for the blood to clot. This is a major concern when Plavix is taken with medications that thin the blood, such as aspirin. Complications that may arise include bleeding of the stomach or the brain. Nose bleeds, bleeding gums or stomach pain may be signs of increased bleeding, as is stool that is dark brown or black. Bleeding in the brain, also known as intracranial hemorrhage, may cause a headache that does not have other possible triggers. Also, if you are having surgery, inform your doctor that your are taking this medication, as you may lose more blood than normal, and may need to stop the medication.
Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura (TTP) is a disorder that causes the formation of blood clots in the vessels of the body. According to Plavix's official website, TTP is rare but potentially life-threatening and has occurred in less than 2 weeks after starting the medication. The symptoms of TTP are fever, unexplained weakness and confusion; seek medical attention if you develop any of these symptoms.
Allergic Reactions
Allergic reactions are rare with Plavix, but some may be life-threatening. Angioedema, which is the swelling of the lips, mouth and tongue, is one effect that may cause difficulty breathing and requires immediate medical help. Some individuals may experience an anaphylactoid reaction. This is characterized by reactions on the skin and in the respiratory tract, heart and central nervous system. Most anaphylactoid reactions involve the skin and are exhibited by itchiness, hives and skin lesion. Symptoms that require immediate attention include difficulty breathing, chest tightness or chest pain and confusion.
References
- "Drug Information Handbook, 15th Edition"; Charles F. Lacy, RPh, PharmD, FCSHP; Lora L. Armstrong, RPh, PharmD, BCPS; et al; 2007
- Plavix: Safety and Side Effects of Plavix
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