Abilify, the trade name for aripiprazole, is a newer-generation antipsychotic agent (also called atypical antipsychotic) that is used to treat schizophrenia, mania and bipolar conditions and--at times--major depressive disorder. Abilify may be used alone or in combination with valproate or lithium, and it is approved for these different uses in children age 10 years through adulthood. However, cautions must be taken with use in the elderly, and numerous side effects are possible in all age groups.
Blood Side Effects
Abilify and other antipsychotics in the same drug class can cause decreased levels of cells in the blood, particularly white blood cells and neutrophils. Clinically called leukopenia and neutropenia, these decreases in blood cells reduce the body's defense against diseases and infections. People who take Abilify and develop a fever or other sign of infection should consult a physician.
Psychoses
Newer-generation antipsychotics like Abilify may profoundly affect the nervous system in some individuals. Elderly patients with dementia-related psychosis should not be prescribed Abilify because of an increased risk of death. Patients in any age group who take Abilify may experience agitation, twitching, restlessness, panic, aggressiveness or rapidly fluctuating mood changes. Any of these side effects may be considered a signal of suicidal behavior and should be evaluated immediately by a clinician.
Blood Sugar Effects
Abilify, like other related antipsychotic agents, may increase blood sugar levels in patients, although the relationship between the drug and blood glucose is still undefined as of early 2010. In patients with diabetes who take these antipsycotic agents, hyperglycemia has occurred at high enough levels to induce ketoacidosis or coma.
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