What Are the Side Effects of Estrogen Therapy?

Estrogen is a naturally occurring hormone that is produced by both women and men.
Women produce estrogen in the adrenal glands, ovaries and fat cells and usually have a higher concentration of the hormone in their system than men. In most cases, the body produces the amounts of estrogen needed for the body to function properly. Menopause and illness, however, can cause levels of estrogen to drop. When this happens, estrogen is offered in supplement forms to re-establish normal levels in the body.

Overgrowth of Tissue

Estrogen causes the lining of the uterus (endometrium) to thicken in preparation for pregnancy. When a women enters menopause, estrogen production gradually decreases. Hormone replacement therapy is used to restore hormone levels in the body. When too much estrogen is supplemented, an overgrowth of endometrial tissue is possible. In some cases, this overgrowth of cells and tissue can result in uterine cancer, if allowed to go untreated.

Blood Clots

Taking estrogen for long periods of time can lead to heart disease and blood clots. At one point, estrogen was supplied after menopause to prevent heart disease. Natural estrogens are safe and can be used effectively. Synthetic estrogens, on the other hand, are difficult for the body to assimilate and can form blood clots and heart problems.
Estrogen causes a thickening of tissues. Endometrial cells have been shown to travel outside of the uterus. Endometriosis can be a result of this. As these thickened cells travel throughout the body, blood clots can form. A heart attack can occur if one of these clots enters the heart. If they enter the brain, a stroke can occur.

Breasts Cysts and Cancers

Diethylstilbestrol (DES) is a synthetic form of estrogen used in hormone replacement therapy. DES can alter the genes necessary for uterine growth and development. Synthetic estrogens work the same way in regards to breast tissue. They cause excessive tissue growth which can block ducts. As the ducts dilate, they cause water and fluid to back up into the tissues. Cysts can develop and eventually may turn into cancer if left untreated.

Heavy Periods

The more overgrown the uterus becomes with endometrial tissue, the heavier the blood flow during the menstrual period. As a result of the excessive amounts of tissue, numerous blood clots may also be passed during the menstrual cycle. Adding progesterone may help to balance the hormones in the system and bring the menstrual cycle back to normal.

References

Article reviewed by Edward Last updated on: Mar 21, 2010

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